Robert W. Woody – A pioneer of protein circular dichroism spectroscopy

A pioneer of protein circular dichroism spectroscopy

Circular dichroism (CD) spectroscopy is by far the most widely used technique for protein secondary structure analysis. A survey of the scientific literature will reveal that Robert Woody (Fig. 1) has undoubtedly been a pioneer in the elucidation of the relationship between CD and protein structure and

In vitro study of drug-protein interaction using electronic absorption, fluorescence, and circular dichroism spectroscopy

In the near future, design of a new generation of drugs targeting proteins will be required. Considering the complex bond between the drug and protein, the structure and stability of the target protein should be considered. So far, a series of in vitro investigations have been conducted with the aim of predicting drug-biological medium interactions. In these studies, use of spectroscopic method...

Circular Dichroism of Protein

Protein characterisation by synchrotron radiation circular dichroism spectroscopy.

Circular dichroism (CD) spectroscopy is a well-established technique for the study of proteins. Synchrotron radiation circular dichroism (SRCD) spectroscopy extends the utility of conventional CD spectroscopy (i.e. using laboratory-based instruments) because the high light flux from a synchrotron enables collection of data to lower wavelengths, detection of spectra with higher signal-to-noise l...

Attosecond circular dichroism spectroscopy of polyatomic molecules.

We describe the roles of multiple electronic continua in high-harmonic generation from aligned molecules. First, we show how the circularity of emitted harmonics tracks the interplay of different electronic continua participating in the nonlinear response. Second, we show that the interplay of different continua can lead to large variations of harmonic phases. Finally, we show how multiple elec...